Brief Bio.
Born in 1980 in Chengdu, China, he received his B.S. degree in Mechanics and Mechanical Engineering from the University of Science and Technology of China in 2004, and his Ph.D. degree in Nanoscience and Nanotechnology from the Hong Kong University of Science and Technology in 2008. He joined the Institute of Physics, Chinese Academy of Sciences, as a Distinguished Researcher and Doctoral Supervisor in 2012, and became a Professor in the School of Physics, Chongqing University in 2015.
Current position:
National Young Talent
Chief Scientist of National "973" Youth Program
Deputy Secretary General of National Talent Association
Vice Chairman of Chongqing Young Leaders Association
Vice President of Chongqing European and American Association
Standing Committee Member of Chongqing Municipal Committee of the Chinese People's Political Consultative Conference
"Lu Jiaxi" Talent Award of Chinese Academy of Sciences, Young Scientist Award of Tokyo Institute of Technology, Top Ten Young Scientists Award of Chongqing, Leading physicist of Chongqing
Laboratory Homepage: http://bmphys.cqu.edu.cn/index.htm
Research interests:
1. cancer biophysics: exploration of new approaches to cancer therapy based on altering the tumor microenvironment.
2. research and application of microfluidic organoid chips.
3. Self-organizing robot clusters, research on the emergent mechanism of self-organizing cluster behavior.
Funded projects.
1. 973 Program for Young Scientists, Ministry of Science and Technology (2013CB837200)
"Molecular mechanism study of 3D micro and nano biochips in liver metastasis of hepatocellular carcinoma and colorectal cancer and its clinical application".
2. Natural Science Foundation (11604030)
"Dynamics of functional elastic blood vessels and its application in the study of major diseases"
3. Natural Science Foundation Facial Project (11474345)
"Collective behavior and kinetics of cancer cells invading tissues in 3-D biochip"
4. Natural Science Foundation of Beijing (7154221)
"Digital image analysis combined with 3-D printing technology to explore in vitro non-invasive diagnosis of cardiovascular FFR"
5. Natural Science Foundation of China (11974066)
"Kinetic study of cancer cell invasion of oriented collagen fibers at mesoscopic scale"
Representative papers:
Gao W., Trung V. P., Shengkai L., Michael W., Junle Q., Yan P., Guo C., Daniel I. G., Simon A. L., Robert H. A., L.Liu, "Emergent Field-Driven Robot Swarm States", Physical Review Letters 126,108002 (2021)
Qihui F., Yu Z., Xiaochen W., Ruipei X.,Yu D., Boyi W., Xiaoyu Y., Ying L., L. Liu, Yunliang L., Ming L., Yuanjin Z., Yang J., Fangfu Y, "Dynamically re‐organized collagen fiber bundles transmit mechanical signals and induce strongly correlated cell migration and self‐organization", Angew. Chem. Int. Ed. DOI:https://doi.org/10.1002/anie.202016084 (2021)
Y. Lv, G. Li, H. Peng, Y. Liu, J. Yao, G. Wang, J. Sun, J. Liu, H. Zhang, G. Chen, L. Liu,"Development of elastic artificial vessels with a digital pulse flow system to investigate the risk of restenosis and vasospasm", Lab on a Chip 20(16):3051-3059(2020)
J. Sun, L. Zhang, L. Cui, X. Luo, G. He,X. Dong, L. He, J. Zhang,J. Sun, G. Chen, Y. Lv, L. Liu,"Gestational age estimation from ultrasound fetal biometrics in China", Clin. Exp. Obstet. Gynecol 47(5): 714-722(2020)
J. Zheng, Y. Cheng, Y. Huang, S.Wang, L. Liu,G. Chen, "Drop impacting on a surface with adjustable wettability based on the dielectrowetting effect", Phys. Fluids 32, 097108 (2020)
G. Chen, J. Zheng, L. Liu, L.Xu, "Application of Microfluidics in Wearable Devices", Small Methods 1900688 (2019)
Y. He, L. Xiong, X. Gao, M. Hai, Y. Liu,G. Wang, G. Chen, J. Shuai, Y. Jiao, X. Zhang, R. Liu, L. Liu,"Morphological quantification of proliferation-to-invasion transition in tumor spheroids", BBA - General Subjects 1864(2019)129460
Y. Zheng, H. Nan, Y. Liu, Q. Fan, X.Wang, R. Liu, L. Liu, "Modeling cell migration regulated by cell extracellular-matrix micromechanical coupling", Physical Review E 100(2019) 043303
R. Liu, K. Song, Z. Hu, W. Cao, J. Shuai,S. Chen, H. Nan, Y. Zhen, X. Jiang, H. Zhang, W. Han, Y. Liao, J. Qu, Y.Jiao, Jing Fan, L. Liu, "Diversity of collective migration patterns of invasive breast cancer cells emerging during microtrack invasion", Physical Review E 99, 062403 (2019)
W. Diao, X. Tong, C. Yang, F. Zhang, C.Bao, C. Hao, L. Liu,M. Li, F. Ye, Q. Fan, J. Wang, Z. Ou-Yang,"Behaviors of glioblastoma cells in in vitro microenvironments", Scientific Reports 9:85(2019)
Y. Wu, W. Chen, Z. Wan, A. Djurisic, X.Feng, L. Liu, G. Chen, R. Liu, Z. He, "Multifunctional atomic force probes for Mn2+ doped perovskite solar cells", Journal of Power Sources 425(2019) 130-137 (2019)
A. Wu, D. Liao, V. Kirilin, K. Lin, G.Torga, J. Qu, L. Liu, J. Sturm, K. Pienta, R. Austin,"Cancer dormancy and criticality from a game theory perspective", Cancer Convergence DOI 10.1186/s41236-018-0008-0 (2018)
H. Xie, Y. Jiao, Q. Fan, M. Hai, J. Yang,Z. Hu, Y. Yang, J. Shuai, G. Chen, R. Liu, L. Liu,"Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy", Plos One 13(10): e0206292 (2018)
Y. Wu, W. Chen, Y. Lin, B. Tu, Z. Wu, R.Liu, L. Liu, A. Djuri?i?, Z. He, "General Method To Define the Type of Carrier Transport Materials for Perovskite Solar Cells via Kelvin Probes Microscopy", ACS Appl. Energy Mater. 1,3984-3991 (2018)
Y. Wu, W. Chen, G. Chen, L. Liu,Z. He, R. Liu, "The Impact of Hybrid Compositional Film/Structure on Organic-Inorganic Perovskite Solar Cells”, Nanomaterials 8(6) doi: 10.3390/nano8060356 (2018)
H. Nan, L. Liang, G. Chen, L. Liu,R. Liu, Y. Jiao, "Realizations of highly heterogeneous collagen networks via stochastic reconstruction for micromechanical analysis of tumor cell invasion", Physical Review E 97 (3)033311 (2018)
K. Song, Z. Wang, R. Liu, G. Chen, L.Liu, "Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases", International Journal of Molecular Science 19(4) doi:10.3390/ijms19040935 (2018)
K. Song, Y. Wu, X. Chen, Y. He, L. Liu, G. Chen, R. Liu, "SKPM study on organic-inorganic perovskite materials", AIP Advances 8 (3) 0351114 (2018)
Y. Liu, X. Zhang, Y. Wu, W. Liu, X. Li,R. Liu, L. Liu, J. Shuai, "Derivation of persistent time for anisotropic migration of cells", Chin. Phys. B Vol.26, No. 12 (2017) 128707 (2017)
Q. Fan, R. Liu, Y. Jiao, C. Tian, James D. Farrell, X. Wang, F. Zhang, W. Yuan, H. Han, J. Chen, Y Yang, X. Zhang, F. Ye, M. Li, Z. Ouyang, and L. Liu, "A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructure reveals complex tumourstroma interactions", Lab on a Chip DOI:10.1039/C7LC00191F (2017)
W. Han, S. Chen, W.Yuan, Q. Fan, J. Tian,X. Wang, L. Chen, X. Zhang, W. Wei, R. Liu, Junle Qu, Y. Jiao, Robert H.Austin, and L. Liu, "Oriented collagen fibers direct tumor cell intravasation", Proc. Natl. Acad. Sci. USA (2016)
R. Liu, Y.Li, and L. Liu, "Single molecule fluorescence spectroscopy for quantitative biological applications", Quantitative Biology 177–191(2016)
G. Wang , X. Wang , T. Liu , R. Liu , and L. Liu, "In vitro experimental models and their molding technology of tumor cell", Acta. Phys. Sin. 65,188700 (2016)
H. Wang, J. Liu, X. Zheng, X. Rong, X.Zheng, H. Peng, Z. S. Li, M. Li, L. Liu, "Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies", Sci. Rep. 5,10945 (2015)
J. Zhu, L. Liang, Y. Jiao, L. Liu, "Enhanced Invasion of Metastatic Cancer Cells via Extracellular Matrix Interface", PLoS ONE 10,1371 (2015)
L. Liu, G.Duclos, B. Sun, J. Lee, A. Wu, Y. Kam, E. D. Sontag, H. A. Stone, J. C. Sturm, R. A. Gatenby and R. H. Austin, "Minimization of thermodynamic costs in cancer cell invasion", Proc. Natl. Acad. Sci. USA 10.1073 (2013)
L. Liu, B.Sun, K. Aw Yong, R. Getzenberg, H. Stone and R. Austin, “Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape”, Proc. Natl. Acad. Sci. USA 108:6853–6856 (2011)（高亮文章）
L. Liu, K.Loutherback, D. Liao, D. Yeater, G. Lambert, A. Estevez-Torres, J. Sturm, R. Getzenberg and R. Austin, “A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces”, Lab on a Chip 10, 1807-1813 (2010)
L. Liu, W.Cao, J. Wu, W. Wen, D. C. Chang and P. Sheng, “Design and Integration of an All-in-One Biomicrofluidic Chip”, Biomicrofluidics 2,034103(2008)
L. Liu, S.Peng, W. Wen and P. Sheng, “Micro Thermo Indicators and Optical-Electronic Temperature Control for Microfluidic Applications”, Appl. Phys.Lett.91, 093513 (2007)
L. Liu, S.Peng, W. Wen and P. Sheng, “ Paperlike thermochromic display”, Appl.Phys. Lett. 90 213508 (2007)
L. Liu, S.Peng, X. Niu and W. Wen, “Microheater fabricated from a conducting composite”, Appl. Phys. Lett. 89, 223521 (2006)
L. Liu, X. Niu, W. Wen and P. Sheng, “Electrorheological fluid-actuated flexible platform”, Appl. Phys. Lett. 88, 173505 (2006)
L. Liu, X.Chen, X. Niu, W. Wen, and P. Sheng, “Electrorheological fluid actuated microfluidic pump”, Appl. Phys. Lett. 89, 083505 (2006)
L. Liu, X.Huang, C. Shen, Z. Liu, J. Shi, W. Wen and P. Sheng, “Parallel-field electrorheological clutch: Enhanced high shear rate performance”, Appl. Phys. Lett. 87, 104106 (2005)
