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刘雳宇

时间:2017-12-28  来源:   作者:

 


简介:

2004年毕业于中国科学技术大学力学与机械工程系,获学士学位;2008年获香港科技大学纳米科学与纳米技术博士学位;之后在美国普林斯顿大学物理系工作,历任博士后研究员,讲师等职务。2012年加入中国科学院物理研究所百人计划,任特聘研究员,博士生导师。2015年加入重庆大学物理学院,任教授,博士生导师。

  人才项目:

国家特聘青年专家;

国家“973”计划青年项目首席科学家;

中科院“百人计划”

中美癌症物理研究联盟(US-China Physical Oncology Alliance)(筹)执行主任;

  社会职务:

国家特聘专家联谊会副秘书长;

重庆市欧美同学会副会长

重庆市政协常务委员

  科研奖励:

中国科学院卢嘉锡人才奖,重庆第三批学术带头人,东京工业大学青年科学家奖,重庆市十佳科技青年奖,2016年重庆市科协首届自然科学优秀学术论文奖。

研究方向:

1. 癌症生物物理:基于改变肿瘤微环境的癌症治疗新方法探索;

2. 微流体生物芯片的设计与开发;

3. 流体研究心血管疾病及手术优化方式。利用3-D打印技术构建人造血管,模拟血液及心血管手术方式,研究支架手术等治疗方案和优化设计;

4.基于医学影像重构和数据分析的胎儿健康标准的研究;

5. 与上述领域相关的力传感机器人的结合与应用 。

承担项目:

1. 科技部“973计划青年科学家专题2013CB837200

三维微纳米生物芯片在肝癌和大肠癌肝转移中的分子机理研究及其临床应用

2. 国家自然科学基金面上项目(11674043

功能性弹性血管的动力学及在重大疾病研究中的应用

3. 国家自然科学基金面上项目(11474345)

“3-D生物芯片中癌细胞侵袭组织的集体行为和动力学研究

4. 国家自然科学基金面上项目(11974066)

“介观尺度下癌细胞侵袭取向性胶原纤维的动力学研究”

5. 重庆大学中央高校基本科研业务费医工融合专项2019CDYGYB007

“三维微流体芯片在癌症个体化诊疗中的应用”

6. 重庆市自然科学基金面上项目cstc2019jcyj-msxmX0477

“胶原纤维取向可控的三维生物芯片中癌细胞的侵袭行为和机理研究”

代表性论文:

1.     Y. Zheng, H. Nan, Y. Liu, Q. Fan, X. Wang, R. Liu, L. Liu, F. Ye, B. Sun, Y. Jiao, "Modeling cell migration regulated by cell extracellular-matrix micromechanical coupling", Physical Review E 100, 043303(2019).

2.     L. Xiong, Y. Liu, R. Liu, W. Yuan, G. Wang, Yi He, J. Shuai, Y. Jiao, X. Zhang, W. Han, J. Qu, L. Liu"Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells", Chin. Phys. B. (2019), 28(10): 108701

3.     Y. Wu, W. Chen, Z. Wan, A. Djurisic, X. Feng, L. Liu, G. Chen, R. Liu, Z. He, "Multifunctional atomic force probes for Mn2+ doped perovskite solar cells", Journal of Power Sources 425(2019) 130-137 (2019)

4.     R. Liu, K. Song, Z. Hu, W. Cao, J. Shuai, S. Chen, H. Nan, Y. Zhen, X. Jiang, H. Zhang, W. Han, Y. Liao, J. Qu, Y. Jiao, Jing Fan, L. Liu, "Diversity of collective migration patterns of invasive breast cancer cells emerging during microtrack invasion", Physical Review E 99, 062403 (2019)

5.     C. Spatarelu, H. Zhang, D. Nguyen, X. Han, R. Liu, Q. Guo, J. Notbohm, L. Liu, Z. Chen, "Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods", ACS Biomaterials Science & Engineering (2019)

6.     W. Diao, X. Tong, C. Yang, F. Zhang, C. Bao, C. Hao, L. Liu, M. Li, F. Ye, Q. Fan, J. Wang, Z. Ou-Yang, "Behaviors of glioblastoma cells in in vitro microenvironments", Scientific Reports 9:85(2019)

7.     A. Wu, D. Liao, V. Kirilin, K. Lin, G. Torga, J. Qu, L. Liu, J. Sturm, K. Pienta, R. Austin, "Cancer dormancy and criticality from a game theory perspective", Cancer Convergence DOI 10.1186/s41236-018-0008-0 (2018)

8.     H. Xie, Y. Jiao, Q. Fan, M. Hai, J. Yang, Z. Hu, Y. Yang, J. Shuai, G. Chen, R. Liu, L. Liu, "Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy", Plos One 13(10): e0206292 (2018)

9.     Y. Wu, W. Chen, Y. Lin, B. Tu, Z. Wu, R. Liu, L. Liu, A. Djuri?i?, Z. He, "General Method To Define the Type of Carrier Transport Materials for Perovskite Solar Cells via Kelvin Probes Microscopy", ACS Appl. Energy Mater. 1, 3984-3991 (2018)

10. Y. Wu, W. Chen, G. Chen, L. Liu, Z. He, R. Liu, "The Impact of Hybrid Compositional Film/Structure on Organic-Inorganic Perovskite Solar Cells”, Nanomaterials 8 (6) doi: 10.3390/nano8060356 (2018)

11. H. Nan, L. Liang, G. Chen, L. Liu, R. Liu, Y. Jiao, "Realizations of highly heterogeneous collagen networks via stochastic reconstruction for micromechanical analysis of tumor cell invasion", Physical Review E 97 (3) 033311 (2018)

12. K. Song, Z. Wang, R. Liu, G. Chen, L. Liu, "Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases", International Journal of Molecular Science 19 (4) doi:10.3390/ijms19040935 (2018)

13. K. Song, Y. Wu, X. Chen, Y. He, L. Liu, G. Chen, R. Liu, "SKPM study on organic-inorganic perovskite materials", AIP Advances 8 (3) 0351114 (2018)

14. Y. Liu, X. Zhang, Y. Wu, W. Liu, X. Li, R. Liu, L. Liu, J. Shuai, "Derivation of persistent time for anisotropic migration of cells", Chin. Phys. B Vol. 26, No. 12 (2017) 128707 (2017)

15. Q. Fan, R. Liu, Y. Jiao, C. Tian, James D. Farrell, X. Wang, F. Zhang, W. Yuan, H. Han, J. Chen, Y Yang, X. Zhang, F. Ye, M. Li, Z. Ouyang, and L. Liu, "A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructure reveals complex tumourstroma interactions", Lab on a Chip DOI:10.1039/C7LC00191F (2017)

16. W. Han, S. Chen, W.Yuan, Q. Fan, J. Tian, X. Wang, L. Chen, X. Zhang, W. Wei, R. Liu, Junle Qu, Y. Jiao, Robert H.Austin, and L. Liu, "Oriented collagen fibers direct tumor cell intravasation", Proc. Natl. Acad. Sci. USA (2016)

17. R. Liu, Y.Li, and L. Liu, "Single molecule fluorescence spectroscopy for quantitative biological applications", Quantitative Biology 177–191 (2016)

18. G. Wang , X. Wang , T. Liu , R. Liu , and L. Liu, "In vitro experimental models and their molding technology of tumor cell", Acta. Phys. Sin. 65,188700 (2016)

19. H. Wang, J. Liu, X. Zheng, X. Rong, X. Zheng, H. Peng, Z. S. Li, M. Li, L. Liu, "Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies", Sci. Rep. 5,10945 (2015)

20. J. Zhu, L. Liang, Y. Jiao, L. Liu, "Enhanced Invasion of Metastatic Cancer Cells via Extracellular Matrix Interface", PLoS ONE 10,1371 (2015)

21. L. Liu, G. Duclos, B. Sun, J. Lee, A. Wu, Y. Kam, E. D. Sontag, H. A. Stone, J. C. Sturm, R. A. Gatenby and R. H. Austin, "Minimization of thermodynamic costs in cancer cell invasion", Proc. Natl. Acad. Sci. USA 10.1073 (2013)

22. L. Liu, B. Sun, K. Aw Yong, R. Getzenberg, H. Stone and R. Austin, “Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape”, Proc. Natl. Acad. Sci. USA 108:6853–6856 (2011)(高亮文章)

23. L. Liu, K. Loutherback, D. Liao, D. Yeater, G. Lambert, A. Estevez-Torres, J. Sturm, R. Getzenberg and R. Austin, “A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces”, Lab on a Chip 10, 1807-1813 (2010)

24. L. Liu, W. Cao, J. Wu, W. Wen, D. C. Chang and P. Sheng, “Design and Integration of an All-in-One Biomicrofluidic Chip”, Biomicrofluidics 2,034103 (2008)

25. L. Liu, S. Peng, W. Wen and P. Sheng, “Micro Thermo Indicators and Optical-Electronic Temperature Control for Microfluidic Applications”, Appl. Phys. Lett. 91, 093513 (2007)

26. L. Liu, S. Peng, W. Wen and P. Sheng, “ Paperlike thermochromic display”, Appl. Phys. Lett. 90 213508 (2007)

27. L. Liu, S. Peng, X. Niu and W. Wen, “Microheater fabricated from a conducting composite”, Appl. Phys. Lett. 89, 223521 (2006)

28. L. Liu, X. Niu, W. Wen and P. Sheng, “Electrorheological fluid-actuated flexible platform”, Appl. Phys. Lett. 88, 173505 (2006)

29. L. Liu, X. Chen, X. Niu, W. Wen, and P. Sheng, “Electrorheological fluid actuated microfluidic pump”, Appl. Phys. Lett. 89, 083505 (2006)

30. L. Liu, X. Huang, C. Shen, Z. Liu, J. Shi, W. Wen and P. Sheng, “Parallel-field electrorheological clutch: Enhanced high shear rate performance”, Appl. Phys. Lett. 87, 104106 (2005)

 

本实验室正在招收博士后研究员若干,欢迎有志生物物理医学的博士加入,详情参见:http://bmphys.cqu.edu.cn/news/Postdoctoral_recruitment.html

实验室长期招聘博士后。同时,热烈欢迎感兴趣的同学报读博士,硕士生。本课题组有“缙云计划”,也欢迎有做实验兴趣的本科生加入,并对你们的科研兴趣全力支持。感兴趣的同学可发邮件到lyliu at cqu.edu.cn,也欢迎随时找刘老师讨论交流!!

实验室主页:http://bmphys.cqu.edu.cn

Email : lyliu at cqu.edu.cn

 

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